- SHARK CARTILAGE :
Therapeutic properties of Shark cartilage:
In spite of the terrible and voracious
image that is had of the protagonist of this I articulate, it is necessary
to say that it is more fiction than reality, of the 300 species of sharks
which they coexist, only 2 are possible to be considered specially dangerous,
the white shark and the shark tiger.
But what it is more going to us to interest of this escualo is his skeleton,
since it will be the valuable one to be able of his cartilage which
we are going to be discovering. For years it has been calling the attention
that the sharks do not suffer certain diseases, such as the cancer,
very common in other animals, as well as in the man.
The sharks skeleton unlike the mammals,
is made up of cartilage and it does not contain a true bony tissue.
One of the most important differences between the bony tissue and cartilaginous
one he is that this it lacks blood vessels, this would explain because
a bony injury can cure in few weeks and a precise injury of cartilage
of an operation for its repair.
In 1976 Dr Langer and his collaborators, describe that cartilage bovine
contains substance that inhibits vascularización of tumors solid
and that when it administered to this substance to rabbits or mice,
they observed that the growth of new blood vessels of the implanted
tumors stopped and consequently stopped the growth of these tumors,
greater problem than amounts had was to have sufficient of cartilage
bovine, since this gross weight constitutes less of 0.6% of his, for
that reason it considered to use to the sharks like source of cartilages
since its compound endoesqueleto totally by cartilage constitutes between
6 % and 10% of its weight, which a priori
The ANGIOGENESIS (from Greek term angio:
blood, genesis: formation)
The process of formation of new blood vessels is essential for certain
biological functions, such as the tissue repair and healing of ulcers.
Also the vascularización plays a fundamental role in the propagation
of diverse diseases.
In 1971 the Dr Judah Folkman of the Childrenipotesis, that later would
be known like the antiangiogénica theory and that fundamentally
they were two:
· Tumors cannot grow without a network
of blood vessels that nourishes them and simultaneously it retires the
remainder substances.
· Inhibition of the development
of the blood vessels could be a possible assault line to treat the cancer.
Dr.Folkman work, puts in evidence the enormous
one to be able therapeutic which they could have compounds able to inhibit
the development of these blood vessels in the treatment of diverse diseases
not only in the cancer but in many diseases like glaucoma neovascular,
the diabetic retinopatía, reumatoide arthritis, osteoartrítis,
hemangiomas which they are characterized by an abnormal proliferation
hair in the children new born, the psoriasis, etc.
SHARK CARTILAGE PROPERTIES IN THE CANCERIGENIC
PROCESSES:
Like inhibitor of the formation of new blood vessels, in 1983, the studies
of Drs. R. Langer and To Lee of the Technological Institute of Massachusetts
reached the conclusion that " the shark cartilage contains a substance
that strongly inhibits the growth of new blood vessels of the solid
tumors. The abundance of this factor in the shark cartilage could help
to explain the peculiarity of tumors in these animals ".
In 1990 the group of the Dr Langer published a work of identification
of the Inhibiting Factor of the angiogénesis Derived from the
Cartilage (Factor IDC). This group purified a protein that inhibited
the angiogénesis in alive and the proliferation and migration
of endoteliales cells in vitro.
In the same year the Dr Oikawa and his collaborators of Japan isolate
an inhibiting factor of the angiogénesis from the shark cartilage.
In 1995, Dr J. Lott (Denton, the USA) I present/display in the First
Alternative and Complementary Medicine Congress a study developed with
inmunocompetentes mice to which tumors had been implanted them.
Historic analysis showed important changes in the transplanted tumors.
In 1996 the Dr McGuire and collaborators of the University of Nebraska,
again demonstrate the antiangiogénica activity of the shark cartilage.
IN INFLAMMATORY ARTHRITIS AND OTHER PROCESSES:
In processes caused or dependent of the angiogénesis like, the
psoriasis, the diabetic retinopatía, glaucoma neovascular, arthritis
reumatoides and the inflammations. In the all of them cartilage of shark
it is an alternative therapy to consider.
The shark cartilage is powerful an antiinflammatory one by its high
content in mucopolisacáridos. The sulphates of condroitina To,
Cs and D are three of these mucopolisacáridos with resisted antiinflammatory
properties. (Greenberg, 1994).
Reumatoide arthritis is a disorder autoinmune in which activated cells
T participate. Colágeno type II is the majority protein of the
cartilage to articulate of the superior vertebrates and it thinks that
it is a potential autoantigen in this disease. The colagen of the shark
cartilage is constituted in two third parts by colagen type II, after
the oral administration of colágeno type II, the suppresors of
cells T in the mucus of the intestine are activated to avoid an answer
of the immune system to this antigen.
The oral administration of colágeno type II is inmuno selective
suppresor for reumatoide arthritis (Rejholec, 1987) (Rauis, 1991) (Greenberg,
1994).
CONTRAINDICATIONS:
Its use to embarrassed people is not recommended, in age of growth or
just operated, also, those people who have suffered a serious disease
recently cardiac, will have to consult with their specialist before
consuming it.
FINAL CONSIDERATIONS:
Results obtained are the sufficiently excellent like offering an opportunity
to this raw material that so and as has been verified, lacks indirect
effect or toxic and can as opposed to happen to be an alternative therapy
viable (single or combined with others) as common ailments as they are
the arthritic and inflammatory cancer, processes, bony problems, etc.
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